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Front Cell Dev Biol. doi: 10.3389/fcell.2023.1135025 Digits in a dish: An in vitro system to assess the molecular genetics of hand/foot development at single-cell resolution. Allison M Fuiten, Yuki Yoshimoto, Chisa Shukunami, H Scott Stadler |
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PLOS ONe doi: 10.1371/journal.pone.0280634 Chondromodulin is necessary for cartilage callus distraction in mice. Kiminori Yukata, Chisa Shukunami, Yoshito Matsui, Aki Takimoto, Tomohiro Goto, Mitsuhiko Takahashi, Atsushi Mihara, Tetsuya Seto, Takashi Sakai, Yuji Hiraki, Natsuo Yasui |
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Biomedicines doi: 10.3390/biomedicines11030772 Dexamethasone Is Not Sufficient to Facilitate Tenogenic Differentiation of Dermal Fibroblasts in a 3D Organoid Model. Niklas Kroner-Weigl, Jin Chu, Maximilian Rudert, Volker Alt, Chisa Shukunami, Denitsa Docheva |
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Front Cell Dev Biol. doi: 10.3389/fcell.2022.780038 Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Yuki Yoshimoto, Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Kaori Tanaka, Xinyi Yu, Tamaki Kurosawa, Shinsei Yambe, Kazumitsu Maehara, Yasuyuki Ohkawa, Yusuke Sotomaru, Chisa Shukunami |
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Front Cell Dev Biol. doi: 10.3389/fcell.2022.898428 Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs. Takenori Omoto, Dilimulati Yimiti, Yohei Sanada, Minoru Toriyama, Chenyang Ding, Yuta Hayashi, Yasunari Ikuta, Tomoyuki Nakasa, Masakazu Ishikawa, Masayuki Sano, Minjung Lee, Takayuki Akimoto, Chisa Shukunami, Shigeru Miyaki, Nobuo Adachi |
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Sci Transl Med doi: 10.1126/scitranslmed.abj5557 The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Ryo Nakamichi, Shang Ma, Takayuki Nonoyama, Tomoki Chiba, Ryota Kurimoto, Hiroki Ohzono, Merissa Olmer, Chisa Shukunami, Noriyuki Fuku, Guan Wang, Errol Morrison, Yannis P. Pitsiladis, Toshifumi Ozaki, Darryl D'Lima, Martin Lotz, Ardem Patapoutian, Hiroshi Asahara |
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Bone. doi: 10.1016/j.bone.2021.115969. Scleraxis upregulated by transforming growth factor-β1 signaling inhibits tension-induced osteoblast differentiation of priodontal ligament cells via ephrin A2. Masayoshi Kawatsu, Nobuo Takeshita, Aki Takimoto, Yuki Yoshimoto, Masahiro Seiryu, Arata Ito, Seiji Kimura, Tadafumi Kawamoto, Yuji Hiraki, Chisa Shukunami, Teruko Takano-Yamamoto. |
Nat Commun. doi: 10.1038/s41467-021-22340-8. (理化学研究所) Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling. Long Guo, Aritoshi Iida, Gandham SriLakshmi Bhavani, Kalpana Gowrishankar, Zheng Wang, Jing-Yi Xue, Juan Wang, Noriko Miyake, Naomichi Matsumoto, Takanori Hasegawa, Yusuke Iizuka, Masashi Matsuda, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki, Shinsei Yambe, Gen Nishimura, Haruhiko Koseki, Chisa Shukunami, Katta M Girisha, Shiro Ikegawa. |
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Curr Issues Mol Biol. doi: 10.3390/cimb43030150. The Identification of Marker Genes for Predicting the Osteogenic Differentiation Potential of Mesenchymal Stromal Cells Masami Kanawa, Akira Igarashi, Katsumi Fujimoto, Tania Saskianti, Ayumu Nakashima, Yukihito Higashi, Hidemi Kurihara, Yukio Kato, Takeshi Kawamoto |
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Int J Mol Sci. doi: 10.3390/ijms222111509. BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma Toshiyuki Nagata, Kentaro Minami, Masatatsu Yamamoto, Tsubasa Hiraki, Masashi Idogawa, Katsumi Fujimoto, Shun Kageyama, Kazuhiro Tabata, Kohichi Kawahara, Kazuhiro Ueda, Ryuji Ikeda, Yukio Kato, Masaaki Komatsu, Akihide Tanimoto, Tatsuhiko Furukawa, Masami Sato |
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Sci Rep. doi: 10.1038/s41598-021-98532-5. CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN. Daisuke Ono, Ken-Ichi Honma, Christoph Schmal, Toru Takumi, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato, Sato Honma |
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PLoS One. doi: 10.1371/journal.pone.0242286. Role of Scx+/Sox9+ cells as potential progenitor cells for postnatal supraspinatus enthesis formation and healing after injury in mice. Katsumasa Ideo, Takuya Tokunaga, Chisa Shukunami, Aki Takimoto, Yuki Yoshimoto, Ryuji Yonemitsu, Tatsuki Karasugi, Hiroshi Mizuta, Yuji Hiraki, Takeshi Miyamoto. |
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Aging Cell. doi: 10.1111/acel.13091. Loss of tenomodulin expression is a risk factor for age-realated intervertebral disc degeneration. Dasheng Lin, Paolo Alberton, Manuel Delgado Caceres, Carina Prein, Hauke Clausen‐Schaumann, Jian Dong, Attila Aszodi, Chisa Shukunami, James C Iatridis, Denitsa Docheva. |
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Development. doi: 10.1242/dev.186239. Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Mao Kuriki, Fuminori Sato, Hiroyuki N. Arai, Maina Sogabe, Mari Kaneko, Hiroshi Kiyonari, Koichi Kawakami, Yuki Yoshimoto, Chisa Shukunami, Atsuko Sehara-Fujisawa. |
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Genes Cells. doi: 10.1111/gtc.12752. DEC1 regulates the rhythmic expression of PPARγ target genes involved in lipid metabolism in white adipose tissue. Noshiro M, Kawamoto T, Nakashima A, Ozaki N, Saeki M, Honda K, Fujimoto K, Kato Y. |
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BMC Biol. doi: 10.1186/s12915-020-00851-y. Novel developmental bases for the evolution of hypobranchial muscles in vertebrates. Kusakabe R, Higuchi S, Tanaka M, Kadota M, Nishimura O, Kuratani, S. |
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Cell Reports. doi: 10.1016/j.celrep.2019.09.019. Metalloprotease-dependent attenuation of BMP signaling restricts cardiac neural crest cell fate. Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A. |
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Am J Sport Med. doi: 10.1177/0363546519836959. Fibroblast growth factor 2 enhances tendon-to-bone healing in a rat rotator cuff repair of chronic tears. Yonemitsu R, Tokunaga T, Shukunami C, Ideo K, Arimura H, Karasugi T, Nakamura E, Ide J, Hiraki Y, Mizuta H. |
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Sci Rep. doi: 10.1038/s41598-019-40810-4. Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/) depends on SOX9-driven transactivation. Takimoto A, Kokubu C, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y, Shukunami C. |
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Sci Rep. doi: 10.1038/s41598-018-21194-3. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y. |
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J Bone Mine Metab. doi: 10.1007/s00774-017-0855-2. THRAP3 interacts with and inhibits the transcriptional activ ity of SOX9 during chondrogenesis. Sono T, Akiyama H, Miura S, Deng JM, Shukunami C, Hiraki Y, Tsushima Y, Azuma Y, Behringer RR, Matsuda S. |
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Nat Commun. doi: 10.1038/s41467-018-03147-6. Host defense against oral microbiota bone-damaging T cells. Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, Iwakura Y, Nakashima T, Okamoto K, Takayanagi H. |
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Biomed Rep. doi: 10.3892/br.2018.1066. Characterization of human dental pulp cells grown in chemically defined serum-free medium. Fujii S, Fujimoto K, Goto N, Abiko Y, Imaoka A, Shao J, Kitayama K, Kanawa M, Sosiawan A, Suardita K, Nishimura F, Kato Y. |
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Stem Cells Int. doi: 10.1155/2018/9530932. Genetic Markers Can Predict Chondrogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stromal Cells. Kanawa M, Igarashi A, Fujimoto K, Higashi Y, Kurihara H, Sugiyama M, Saskianti T, Kato Y, Kawamoto T. |
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Genes Cells. doi: 10.1111/gtc.12607. Deficiency of the basic helix-loop-helix transcription factor DEC1 prevents obesity induced by a high-fat diet in mice. Noshiro M, Kawamoto T, Nakashima A, Ozaki N, Ueno T, Saeki M, Honda K, Fujimoto K, Kato Y. |
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EBioMedicine. doi: 10.1016/j.ebiom.2017.05.003. Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load. Dex S, Alberton P, Willkomm L, Sollradl T, Bago S, Milz S, Shakibaei M, Ignatius A, Bloch W, Clausen-Schaumann H, Shukunami C, Schieker M, Docheva D. |
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Am J Sports Med. doi: 10.1177/0363546517707940. TGF-β1 Improves Biomechanical Strength by Extracellular Matrix Accumulation Without Increasing the Number of Tenogenic Lineage Cells in a Rat Rotator Cuff Repair Model. Arimura H, Shukunami C, Tokunaga T, Karasugi T, Okamoto N, Taniwaki T, Sakamoto H, Mizuta H, Hiraki Y. |
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Scientific Reports 2017; 7: 45010. doi:10.1038/srep45010(広島大学) (京都大学) Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system Yuki Yoshimoto, Aki Takimoto, Hitomi Watanabe, Yuji Hiraki, Gen Kondoh, Chisa Shukunami |
総説・出版物等 |
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CLINICAL CALCIUM(医薬ジャーナル社) 2017年3月号 vol.27 No.3 P43(367)〜49(373) 特集 筋肉研究の最前線 腱・靱帯と骨格筋 宿南知佐 |
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Stem Cells Int. 2016:8035759. doi: 10.1155/2016/8035759 Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells. Goto N, Fujimoto K, Fujii S, Ida-Yonemochi H, Ohshima H, Kawamoto T, Noshiro M, Shukunami C, Kozai K, Kato Y. |
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Int. J. Mol. Med. 38(3), 876-884 DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells. Sasamoto T, Fujimoto K, Kanawa M, Kimura J, Takeuchi J, Harada N, Goto N, Kawamoto T, Noshiro M, Suardita K, Tanne K, Kato Y. |
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Biomed. Rep. 4:704-710 Rhythmic expression of DEC2 protein in vivo and in vitro. Sato F, Muragaki Y, Kawamoto T, Fujimoto K, Kato Y, Zhang Y. |
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PLoS Genetics 12:e1005802, 2016. doi:10.1371/journal.pgen.1005802(広島大学) (京都大学) Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: Elevated expression of the ladybird homeobox gene causes body axis deformation Long Guo, Hiroshi Yamashita, Ikuyo Kou, Aki Takimoto, Makiko Meguro-Horike, Shin-ichi Horike, Tetsushi Sakuma, Shigenori Miura, Taiji Adachi, Takashi Yamamoto, Shiro Ikegawa, Yuji Hiraki, Chisa Shukunami |
総説・出版物等 |
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Keynote RA（先端医学社） vol.4 No.4 p20-25 靭帯の形成と再生 吉本由紀, 滝本 晶, 宿南知佐 |
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Gene 1;587(1):1-17 TENOgenic MODULating INsider factor : Systematic assessment on the functions of TNMD gene. Dex S, LinD, Shukunami C, Docheva D. |
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Jap. Dent. Sci. Rev. 52(4), 84-92 Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components. Shukunami C, Yoshimoto Y, Takimoto A, Yamashita H, Hiraki Y. |
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Scientific Reports 5:16455, 2015. doi: 10.1038/srep16455. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Cui M, Kanemoto S, Cui X, Kaneko M, Asada R, Matsuhisa K, Tanimoto K, Yoshimoto Y, Shukunami C, Imaizumi K. |
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Biochem Biophys Rep. 3:175-189, 2015. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Sakamaki K, Iwabe I, Iwata H, Imai K, Takagi C, Chiba K, Shukunami C, Tomii K, Ueno N. |
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Am J Sports Med. 43:2411-2422, 2015. FGF-2 stimulates the growth of tenogenic progenitor cells to facilitate the generation of Tenomodulin-positive tenocytes in a rat rotator cuff healing model. Tokunaga TS, Shukunami C. Okamoto, N. Okada, T. Taniwaki, T. Oka, K. Sakamoto H. Mizuta H. Hiraki Y. |
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Am J Hum Gen. 97:337-342, 2015. A functional SNP in BNC2 up-regulates BNC2 expression and increases the risk of adolescent idiopathic scoliosis. Ogura Y, Kou I, Takahashi A, Miura S, Xu L, Takahashi Y, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yonezawa I, Yanagida H, Taneichi H, Zhu Z, Tsuji T. Suzuki T, Sudo H, Kotani T, Watanabe K, Hosogane N, Okada E, Sudo A, Chiba K, Toyama Y, Imai Y, Sawasaki T, Qiu Y, Shukunami C, Kubo M, Matsumoto M, Ikegawa S. |
Development 142:787-796, 2015.  Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone. Takimoto A, Kawatsu M, Yoshimoto Y, Kawamoto T, Seiryu M, Takano-Yamamoto T, Hiraki Y, Shukunami C. |
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Stem Cells Dev. 24:597-609, 2015. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells. Alberton P, Dex S, Popov C, Shukunami C, Schieker M, Docheva D. |
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Biomed. Rep. 3(4), 566-572, 2015. Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells. Fujii S, Fujimoto K, Goto N, Kanawa M, Kawamoto T, Pan H, Srivatanakul P, Rakdang W, Pornprasitwech J, Saskianti T, Suardita K, Nishimura F, Kato Y. |
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Front. Neurol. 6:166, 2015. DEC2-E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter. Tanoue S, Fujimoto K, Myung J, Hatanaka F, Kato Y, Takumi T. |
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Biomed. Res. 36(2), 89-96, 2015. Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, Takai Y, Kijima H. |
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Int. J. Mol. Med. 35(3), 815-820, 2015. Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2. Wu Y, Sato H, Suzuki T, Yoshizawa T, Morohashi S, Seino H, Kawamoto T, Fujimoto K, Kato Y, Kijima H. |
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The Journal of Hiroshima University Dental Society 47, 32-40, 2015. Effects of fibronectin on spreading, proliferation, and differentiation of mesenchymal stem cells under serum-free conditions. Veronica Sainik Ronald. |
総説・出版物等 |
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日本骨代謝学会編集 (羊土社) 骨ペディア 骨疾患・骨代謝キーワード事典 p25-29 骨の血管・神経 宿南 知・ｲ |
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日本再生医療学会監修 (メディカルトリビューン) 再生医療 用語ハンドブック p106-109 腱・靱帯細胞 (p106-107), Chondromodulin-I (p108), Tenomodulin (p108-109), Scleraxis (p109) 宿南 知佐 |
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THE BONE vol.29 No.3 p63-68 筋と骨をつなぐ臓器：腱と筋膜(Development and integration of the musculoskeletal system) 吉本 由紀, 山下 寛, 宿南 知佐 |
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整形・災害外科 58 巻 10号 p1373-1379 腱・靱帯形成の制御 滝本 晶, 吉本 由紀, 山下 寛, 宿南 知佐 |
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Journal of Cell Science 127:1875-1886, 2014. The role of the interaction of vinculin proline-rich linker region with vinexin in sensing stiffness of the extracellular matrix Yamashita H, Ichikawa T, Matsuyama D, Kimura Y, Ueda K, Craig S W,Harada I, Kioka N. |
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PLoS One 9:e94239, 2014. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development. Miura S, Kondo J, Takimoto A, Sano-Takai H, Guo L, Shukunami C, Tanaka H, Hiraki Y. |
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J Cardio. Dev Dis. 1:163-176, 2014. Sox9- and Scleraxis-Cre Lineage Fate Mapping in Aortic and Mitral Valve Structures. Austin BF, Yoshimoto Y, Shukunami C, Lincoln J. |
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PLoS Biology 12(4), e1001839, 2014 A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. Goriki A, Hatanaka F, Myung J, Kim JK, Yoritaka T, Tanoue S, Abe T, Kiyonari H, Fujimoto K, Kato Y, Todo T, Matsubara A, Forger D, Takumi T. |
総説・出版物等 |
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Current topics in developmental biology 110, 339-372. DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli. Kato Y, Kawamoto T, Fujimoto K, Noshiro M. |
| 原著論文 |
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Experimental Cell Resarch 319:3128-3139, 2013. Pax1 acts as a negative regulator of chondrocyte maturation. Takimoto A, Mohri H, Kokubu C, Hiraki Y, Shukunami C. |
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Genesis 51:275-283, 2013. Generation and characterization of ScxCre transgenic mice. Sugimoto Y, Takimoto A, Hiraki Y, Shukunami C. |
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Development 140:2280-2288, 2013. Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament. Sugimoto Y, Takimoto A, Akiyama H, Kist R, Scherer G, Nakamura T, Hiraki Y, Shukunami C. |
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Nature Genetics 45:676-679, 2013. Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis. Kou I, Takahashi Y, Johnson TA, Takahashi A, Guo L, Dai J, Qiu X, Sharma S, Takimoto A, Ogura Y, Jiang H, Yan H, Kono K, Kawakami N, Uno K, Ito M, Minami S, Yanagida H, Taneichi H, Hosono N, Tsuji T, Suzuki T, Sudo H, Kotani T, Yonezawa I, Londono D, Gordon D, Herring JA, Watanabe K, Chiba K, Kamatani N, Jiang Q, Hiraki Y, Kubo M, Toyama Y, Tsunoda T, Wise CA, Qiu Y, Shukunami C, Matsumoto M, Ikegawa S. |
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PLoS One 8:e60203, 2013. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI. |
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Journal of Biochemistry 154, 373-381, 2013. Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light-dark conditions. Honda K K, Kawamoto T, Ueda H R, Nakashima A, Ueshima T, Yamada R G, Nishimura M, Oda R, Nakamura S, Kojima T. |
総説・出版物等 |
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Pharma. Medica. 31:43-46 腱・靭帯形成の制御メカニズム 宿南 知佐 |